Based on this statement, the biggest hurdle to Guy Pearce returning might be the fact his collaborators from Iron Man 3 wouldn’t be involved. At this point, it seems clear that both Robert Downey, Jr. and Gwyneth Paltrow have moved on from the MCU. We certainly could see Shane Black direct another entry in this particular cinematic universe, but I get the feeling if Black wanted to return, and Marvel wanted him back, that would have happened by now.
Guy Pearce’s time in the MCU is available on Disney+. You can use this link to sign up for the streaming service.